Human Papilloma Virus

Pathogen Challenge


  • Pat Stringfellow Canadian Association of Physician Assistant


Human Papilloma Virus, HPV Vaccine



Purpose. A review of the history and discovery of the human papiloma virus, was conducted along with the development and difficulities of distribution of the vaccine.

Method. Articles from PubMed, CDC, and FDA were reviewed.

Results. Reading from the journals show a long duration of time from when the disease was initially introduced, to recognition and finally development of a vaccine.

Conclusion. Despite acknowledgement that the vaccine has the pontial to reduce or even rid the disease and so reduce the number of cancers originating from the virus, there are still groups who feel the vaccine has no place in their society.



Cervical cancer. Accessed Oct 29, 2020.

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Suzich JA, Ghim SJ, Palmer-Hill FJ, et al. Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas. PNAS. 1995;92(25):11553-11557. Accessed Oct 29, 2020.

Gardasil (human papillomavirus quadrivalent (types 6, 11, 16, and 18) vaccine, recombinant) FDA approval history. Accessed Oct 29, 2020.

What everyone should know | human papillomavirus (HPV) vaccination | vaccination and immunization | CDC. Updated 2020. Accessed Oct 29, 2020.

Nour NM. Cervical cancer: A preventable death. Reviews in obstetrics and gynecology. 2009;2(4):240-244.

Gilkey MB, Calo WA, Marciniak MW, Brewer NT. Parents who refuse or delay HPV vaccine: Differences in vaccination behavior, beliefs, and clinical communication preferences. Human Vaccines & Immunotherapeutics. 2017;13(3):680-686. Accessed Nov 1, 2020.




How to Cite

Stringfellow, P. (2021). Human Papilloma Virus: Pathogen Challenge. The Journal of Canada’s Physician Assistants, 3(7). Retrieved from